唤醒哺乳动物的潜在再生能力

Extrinsic factors can create a local tissue environment that encourages restoration Julia C. Paoli and Jessica L. Whited The ability to regenerate varies widely across the animal kingdom. Planarians, a type of flatworm, can rebuild their entire body from small fragments. Fish and salamanders can regenerate complex structures such as fins and limbs (1). By contrast, mammals exhibit much more limited natural regenerative abilities (2). This disparity has profound clinical consequences. Poor wound healing, scarring, and limb loss continue to diminish quality of life (3–5). Defining how animals orchestrate regenerative processes is important for developing therapies for humans. Emerging evidence suggests that the genes carried by mammals may not render them intrinsically regeneration incompetent (6–10). …