胎盘NAD+调节分娩时机

Placental nicotinamide adenine dinucleotide modulates the timing of labor Erin J. Ciampa1*, Luana M. Machado1, Kathy J. Lee1, Amanda J. Clark2, Kyle Q. Vu2, Nawal A. Khan3, Sarah Kispert1, Samantha Armstrong1, Yunping Li1, Ginger L. Milne4†, Ashley Solmonson3, S. Ananth Karumanchi5, Samir M. Parikh6,7* Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (nAD+) dynamically tunes gestational length. …