晨间信号Morning Signal
《科学》 第393卷 第6810期 · 2026年7月30日 · 中文解读

南美洲早期天花病毒的基因组身份

The genomic identity of early smallpox in South America · B. Romero González et al.
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本文报道了来自智利北部印加-殖民时期个体的两个古代天花基因组,揭示了其与欧洲殖民传播相关的已灭绝谱系,并分析了基因失活和替代率变化。
原文开头
Bruno Romero González1, Margarita Reyes- Madrid2, Bernardo Arriaza3, Lara M. Cassidy4, Mauricio Moraga2,5, Constanza de la Fuente Castro2*, Shigeki Nakagome1,6* Smallpox was a major driver of population collapse in the Americas after European contact, yet the genetic identity of the causal strains remains unknown. Here, we report the first ancient smallpox genomes in the Americas, dating to approximately 1492–1631 common era (CE), recovered from two Inca-Colonial individuals in northern Chile. These genomes form a now-extinct lineage that diverged around 1296 CE, after the splitting of early medieval European strains but before the emergence of modern variola lineages, providing direct molecular evidence for smallpox introduction through European colonization. …
摘自《科学》(Science)第393卷 第6810期 · 2026年7月30日,B. Romero González et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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