时空多组学揭示转移定植过程中肿瘤生态系统的动态变化

Full article and list of author affiliations: https://doi.org/10.1126/ science.adz7928 Yunfan Sun (孙云帆)*†, Yu Zhong (钟裕)†, Shang Liu (刘尚)†, Zefan Zhang (张泽凡)†, Chunqing Wang (王春青)†, Yang Liu (刘旸)†, Junbing Chen (陈俊冰)†, Wei Guo (郭玮)† et al. INTRODUCTION: Metastasis is the primary cause of cancer- related mortality, yet the earliest event of colonization, where the fate of disseminated tumor cells (DTCs) is decided, remains largely unknown. Although most DTCs are eliminated on arrival in secondary organs, a resilient minority survives to initiate lethal outgrowth. Capturing these rare, transient populations in clinical specimens is technically challenging, and precise molecular mechanisms that allow DTCs to evade immune surveillance and remodel their local environment are currently unclear. …