DNA polymerization activates RNA cleavage of a reverse transcriptase–like antiviral enzyme · X. Rong et al.
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Xuejun Rong (荣雪君)1 †, Jun Xiao (肖军)2†, Xinyuan Zhao (赵新元)1†, Yan Yan (闫艳)1 †‡, Jing Li (李静)2†, Yifan Chen (陈逸凡)1, Yihua Fan (范益华)2, Zhichao Liu(刘志超)1, Yue Cao (曹越)1, Fan Chen (陈凡)2, Rui Cheng (成锐)1, Xionglue Wang (王雄略)1*, Longfei Wang (王隆飞)2*, Bin Zhu (朱斌)1,3* Defense- associated reverse transcriptases (DRTs) transcribe noncoding RNAs (ncRNAs) for antiviral defense, but the mechanisms of ncRNA- independent DRTs remain unclear. In this work, we show that a single DRT4 mediates RNA- targeting antiphage defense by integrating DNA polymerase, exonuclease, and RNA endonuclease activities. …
摘自《科学》(Science)第393卷 第6810期 · 2026年7月30日,X. Rong et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。