单个细胞器中的衰老与疾病特征

Changes in lysosomal metabolites are associated with both aging organs and lysosomal storage diseases Jeeyoon Na1,2 and Anne Brunet1,3 Lysosomes are central to cellular metabolism, and their function declines substantially in many degenerative diseases and during aging (1–5). But how content of these organelles changes with age and whether these changes differ across tissues remain unknown. On page 488 of this issue, Puszynska et al. (6) describe a multitissue atlas of lysosomal metabolites during aging. Several metabolites accumulate with age across multiple tissues in several mammalian species. Notably, those that increase with age also accumulate in lysosomal storage disorders—devastating diseases that predominantly affect children—providing an intriguing connection between these diseases and aging. …