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《新科学家》 第269卷 第3581期 · 2026年2月7日 · 中文解读

阿尔茨海默病抵抗力的关键何在?

Is this the key to Alzheimer’s resilience? · Grace Wade
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这篇讲什么
本文探讨了为何有些人尽管大脑中出现阿尔茨海默病的病理变化却不发展成痴呆,并介绍了两项研究揭示的潜在保护机制。
原文开头
We are now starting to understand why some people don’t develop dementia despite showing signs of Alzheimer’s disease in their brain, reports Grace Wade PEOPLE with Alzheimer’s-related brain changes, but no symptoms of the disease, have unusual changes in their brain that may shield them from cognitive decline. By analysing brain scans, we can better understand the spread of Alzheimer’s they died, and all of them had completed a cognitive assessment less than a year before death. In Alzheimer’s disease, clumps of misfolded proteins known as amyloid plaques and tau tangles build up in the brain, which is widely thought to drive cognitive decline. But not everyone with these hallmarks experiences symptoms – a phenomenon known as resilience. …
摘自《新科学家》(New Scientist)第269卷 第3581期 · 2026年2月7日,Grace Wade。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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