社会记忆效价更新的神经回路

Narutoshi Suto, Mu- Yun Wang, Shota Morikawa, Myung Chung, Kentaro Tao, Ziyan Huang, Yuji Ikegaya, Haruki Takeuchi, Shinichiro Kira, Teruhiro Okuyama* INTRODUCTION: Social animals recognize familiar conspecifics and assign valence based on prior social interactions. This ability allows individuals to promote adaptive social interactions while minimizing the cost of antagonistic encounters. Because social relationships are dynamic, the capacity to continuously update the valence attributed to specific individuals is essential. Although hippocampal ventral CA1 (vCA1) neurons encode social memory, the neural circuit mechanisms that selectively update social valence remain largely undefined. RATIONALE: We hypothesized that valence updating for familiar individuals is mediated by circuit- specific interactions between social memory representations in vCA1 and downstream valence- processing pathways. …