细菌通过FhaB介导的微管结合蛋白递送促进宿主定殖

Bacteria deliver a microtubule- binding protein into mammalian cells to promote colonization Michael S. Costello1, Bryan Neumann2, Mia W. Raimondi1, Bonnie J. Cuthbert2, Jana Holubová3, Fernando Garza-Sánchez1, Abdul Samad3, Ladislav Bumba3, Jacob A. Torres1, Nickolas Holznecht1, Jessica Mendoza2, Ondrej Stanek3, Sasiprapa Prombhul2, Thomas Weimbs1,4, Meghan A. Morrissey1, Diego Acosta-Alvear1,5, David A. Low1,6, Peter Šebo3, Celia W. Goulding2,7, Shane Gonen2*, Christopher S. Hayes1,6* Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetella carries a C-terminal microtubule-binding domain (FhaB-CT), which is translocated into host cells to promote colonization. …