纠错机制的演化：速度需求驱动下的新视角

Riccardo Ravasio†, Kabir Husain†, Constantine G. Evans, Rob Phillips, Marco Ribezzi-Crivellari, Jack W. Szostak, Arvind Murugan* INTRODUCTION: Multistep assembly processes in biology are prone to errors, and as a result, diverse error correction strategies have evolved. For example, polymerases can excise an incorrect nucleotide by proofreading, transcription complexes can back- track, and incorrectly assembled partial structures can be disassembled before trying again. These error-correcting mecha- nisms take time, leading to the widely held view that increased accuracy comes at the inevitable cost of slower replication or assembly. Error-correcting mechanisms are therefore thought to have evolved because errors in sequence or assembly are so deleterious that they must be corrected despite the additional time it takes to correct them. …