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《科学》 第391卷 第6787期 · 2026年2月19日 · 中文解读

食欲素驱动的θ振荡促进共情与亲社会行为

Empathy and prosocial behavior powered by orexin-driven theta oscillations · J. G. Kim et al.
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研究发现,小鼠前扣带回皮层中由外侧下丘脑食欲素能输入驱动的5-7Hz θ振荡,在观察性恐惧和亲社会理毛行为中发挥关键作用,且这种作用依赖于先前的恐惧经历。
原文开头
Jae Gon Kim1, Greg O. Cron1, Minsoo Kim1, Aronee Hossain1, Jin Hyung Lee1,2,3,4* Empathy measured through observational fear in rodents has been associated with increased theta oscillations in the anterior cingulate cortex (ACC). However, upstream circuit mechanisms modulating these oscillations and the extent of the oscillations’ role in empathy-related behaviors remain elusive. We found that in mice, ACC theta oscillations are involved in empathy-driven prosocial allogrooming. Moreover, orexinergic neurons are selectively activated in the ACC during observational fear and prosocial allogrooming, but only when the animals had prior fear experience. Real-time, gaze-dependent optogenetic inhibition of lateral hypothalamic orexinergic inputs to ACC suppressed theta power and reduced both behaviors. …
摘自《科学》(Science)第391卷 第6787期 · 2026年2月19日,J. G. Kim et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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