《新科学家》 2026年10月10日 · 中文解读
按压骨骼释放分子,缓解创伤性脑损伤
Compressing bones releases molecules that ease traumatic brain injuries · Tosin Thompson
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每天用力按压小腿骨几分钟,就能显著改善创伤性脑损伤小鼠和猪的运动与认知能力。中国广州南方医科大学的Xiaochun Bai团队发现,骨细胞中的Piezo1离子通道感知机械力后,会释放BDNF、PF4和多巴胺等分子,经血液作用于大脑。德国马克斯·普朗克物理与医学中心的Kristian Franze认为,这揭示了一种此前被低估的骨-脑通讯系统,或可带来新的治疗思路。
原文开头
FIRMLY pressing down on shin bones for just a few minutes every day drastically improved movement and cognition in mice and pigs one week after they had a traumatic brain injury. The intervention stimulates bone cells that are sensitive to physical force, causing them to release substances that promote good brain health. “This is big news to me, as it reveals a previously underappreciated bone-brain communication system, and could potentially lead to new therapeutic approaches in the future,” says Kristian Franze at the Max Planck Center for Physics and Medicine in Germany, who wasn’t involved in the work. …
摘自《新科学家》(New Scientist)2026年10月10日,Tosin Thompson。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。

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