微管动力学控制心肌细胞生长方向

Emily A. Scarborough, Rani M. Randell, Keita Uchida, Kathlyene R. Stone, Kenneth B. Margulies, Benjamin L. Prosser* INTRODUCTION: The heart adapts to stress by altering the thickness and geometry of the myocardial walls. This organ- level remodeling is driven primarily by the growth of individual heart muscle cells, or cardiomyocytes. Cardiomyocytes can add contractile units along their width or length to promote wall thickening or thinning—known as concentric and eccentric remodeling, respectively. Growth along these different axes produces fundamentally distinct functional adaptations and pathological consequences, yet the molecular mechanisms that spatially coordinate cardiac growth have remained unclear. RATIONALE: Microtubules are dynamic cytoskeletal filaments that organize intracellular transport, RNA localization, and protein synthesis and are required for generalized cardiac growth. …