Improve genetic quality control to increase rigor and reproducibility of mouse research · Fernando Pardo-Manuel de Villena et al.
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A quality control process using the latest technology can help address inconsistencies and expectations Fernando Pardo-Manuel de Villena1,2,3, James M. Amos-Landgraf4, Timothy A. Bell1, Matthew W. Blanchard1,2, Jennifer Brennan2, Charisse Carlson5, Dominic J. Ciavatta1,2,6, Paul A. Cotney1, Martin T. Ferris1, Pablo Hock1,2, Ian Korf5,7, K. C. Kent Lloyd7,8,9, Cathleen Lutz10, Rachel M. Lynch1,2, Terry Magnuson1,2,3, Stephen A. Murray10, Samit Patel5, Laura G. Reinholdt10, John Sebastian Sigmon2,11, Brandon Willis9, James G. Xenakis1 R eproducibility of research involving laboratory mouse strains requires rigorous genetic quality control (GQC) for engineered alleles and for strain genetic background, both of which dictate phenotype (1, 2). …
摘自《科学》(Science)第392卷 第6799期 · 2026年5月14日,Fernando Pardo-Manuel de Villena et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。