支架增强细菌疗法

Stiff, tough hydrogel layers that host bacteria enable sustained release of therapeutic molecules Kaige Chen and Quanyin Hu Engineered cells can sense disease and deliver drugs at a site of pathology. These living thera- peutics provide localized, self-sustaining re- sponses to environmental changes, such as inflammation and pathogenic signals, that con- ventional drugs cannot offer (1, 2). A promising chassis for living therapeutics is bacteria, which can be genetically programmed to release drugs in response to an external signal. However, bacteria require physical enclosure to prevent uncontrolled spread and toxicity (3). Biomateri- als such as hydrogels and core-shell capsules have only demonstrated short-term containment of up to 2 weeks in culture (4, 5). …