晨间信号Morning Signal
《科学》 第392卷 第6805期 · 2026年6月25日 · 中文解读

抗生素刺激蛋白质向持留细胞转移

Antibiotics stimulate protein transfer to persister cells
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这篇讲什么
该研究通过遗传系统直接证明,抗生素可诱导细菌通过膜囊泡进行水平蛋白质转移,并促进持留菌的形成。
原文开头
Full article and list of author affiliations: https://doi.org/10.1126/ science.adx3972 Alice X. Wen, Julia Bos*†, Debojyoti Panda†, Katelin M. Hagstrom, Shubham Singh, Shrawan Kumar Mageswaran, Xiaoli Wang, Bo Hu, Kobie T. Welch, Matthew B. Cooke, Jennifer A. Halliday, Laura Deus Ramirez, Antoinette E. Martinez, Yi- Wei Chang, David A. Weitz, Christophe Herman* INTRODUCTION: Bacterial cells exchange biological material, such as DNA and signaling molecules, to promote adaptation in stressful conditions, such as antibiotic exposure. Whereas horizontal gene transfer is known to spread antibiotic resistance genes, far less is understood about the mechanisms and effect of horizontal protein transfer. Bacterial membrane vesicles, which contain proteins, have been proposed as mediators of horizontal protein transfer. …
摘自《科学》(Science)第392卷 第6805期 · 2026年6月25日。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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