Vδ7 TCR与IL17RA直接相互作用驱动TH1样γδT细胞分化

Direct interaction of Vδ7 TCRs with IL17RA drives the differentiation of TH1- like γδT cells Kewei Ye et al. INTRODUCTION: In stark contrast to B cells and αβT cells, γδT cells are the only class of adaptive lymphocytes for which the principles of antigen recognition remain enigmatic. Although the nature of antigens recognized by γδT cells is largely elusive, multiple lines of evidence suggest that endogenous ligands stimulate γδT cell antigen receptors (γδTCRs) to drive the differentiation of effector γδT cell subsets. Although several such molecules have been identified, in most cases, the existence of these ligands remains speculative, and the majority of γδTCRs remain orphan receptors. …