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Generative artificial intelligence can scale precision evidence-based psychotherapy Nicholas C. Jacobson T he world is experiencing a mental health crisis where the prevalence of psychiatric disorders is approximately one in five people in any given year, and the rates have been rising in the past decade (1–3). However, the global median number of mental health providers is only 13 per 100,000 individuals (4). Human providers simply cannot scale to meet this rapidly increas- ing treatment demand. Although the focus has turned to digital mental health interventions to provide further access (5), these interventions mostly apply one-size-fits-all models that fail to target patients’ most common presenting problem: psychiatric comorbidity (6). …