淋巴结不再是必需：树突状细胞亚群在肿瘤组织中协调三级淋巴结构的形成

A subset of dendritic cells orchestrates the formation of tertiary lymphoid structures in tumor tissues William K. Decker I magine an encampment of immune cells positioned precisely where needed—inside a diseased tissue, poised to maintain a co- ordinated attack. As it turns out, such cellular command bases do exist and are known as tertiary lymphoid structures (TLSs). At times referred to as mini or inducible lymph nodes, their for- mation, organization, function, and relevance to nonlymphoid tissues have been long-standing mysteries since initially characterized in 1992 (1). Yet even the strong correlation between the incidence of tumor- localized TLSs and survival after cancer immunotherapy treatments has failed to fully squelch numerous controversies in the field. …