阿尔茨海默病可能起源于大脑之外

Alzheimer’s may start outside the brain Inflammation in organs like the skin, lungs and gut during midlife may trigger Alzheimer’s disease in later years. If so, we will need to totally rethink how we treat the condition, reports Alice Klein ALZHEIMER’S disease has long been viewed as something that originates inside the brain, but an in-depth genomic analysis suggests it may initially be triggered by inflammation in distant organs such as the skin – perhaps decades before a person’s memory starts to decline. This radical reframing of the condition may explain why Alzheimer’s drugs have been disappointing to date: because they act too late in the disease process. …