果蝇主动寻找黑暗以重启生物钟

ciRcaDiaN RhYthMs Fruit flies actively restart their circadian clock by proactively shaping their environment Angelica Coculla, Luis Garcia Rodriguez, Maite Ogueta, Ralf Stanewsky* Circadian clocks provide adaptive advantages, enabling organisms to adjust their physiology and behavior to daily environmental changes on Earth. Here, we show that fruit flies prefer a temporally organized life. Because of light- induced degradation of the core circadian clock protein Timeless, constant illumination stops the circadian clock and leads to arrhythmic locomotor activity. When given the choice to move between dark and illuminated areas in a constant light environment, flies were able to maintain, or even regain, rhythmic behavioral patterns. …