植物免疫：表面免疫信号通过mRNA可变剪接解锁NLR激活

Surface immune signaling unlocks NLR activation through mRNA alternative splicing Chuyun Gao1†, Xi Meng1†, Xianchu Chen1, Leiyun Yang1, Tarhan Ibrahim2, AmirAli Toghani3, Enoch Lok Him Yuen2, Nick Eilmann2, Freddie King2, Kangping Li1, Luyao Wang1, Biying Sun1, Yuanchao Wang1, Tolga Osman Bozkurt2*, Suomeng Dong1* Plants activate pattern-triggered immunity (PTI) and effector- triggered immunity (ETI) to combat pathogens. However, how these systems coordinate immune activation while preventing autoimmunity remains poorly understood. In this study, we uncovered a regulatory mechanism in which surface immune signaling unlocks nucleotide-binding leucine-rich repeat (NLR) immune receptor activation through mRNA splicing. We identified an N-terminal prodomain in the potato late blight resistance protein Rpi-vnt1.1 that inhibits resistosome formation, preventing potential autoactivation of this NLR. …