ILC2调控胰腺成纤维细胞祖细胞生态位

Full article and list of author affiliations: https://doi.org/10.1126/ science.aea5113 Thomas Yip et al. INTRODUCTION: Fibroblasts are central regulators of organ health and disease, although it remains unclear how different fibroblast subsets are controlled within tissues. Recently, both murine and human fibroblast atlases have revealed the presence of a conserved fibroblast subset that is present in many organs and disease states, marked by Pi16+Dpp4+Ly6c+ gene expression, and computationally predicted to have progenitor capacity. Notably, these fibroblasts are also reported to express high Il33, encoding the alarmin IL- 33, which can stimulate Group 2 innate lymphoid cells (ILC2s). ILC2s are tissue- resident immune cells that can promote fibroblast activation and are also emerging as regulators of epithelial stem cell niches. …