激素细胞图谱：以细胞分辨率绘制人类内分泌系统

Full article and list of author affiliations: https://doi.org/10.1126/ science.aeb2672 Lijiang Fei†, Isabel Huang- Doran†, et al. INTRODUCTION: Hormones are chemical messengers secreted into the blood, which act on distant targets to coordinate fundamental physiological processes, such as growth, reproduction, and metabo- lism. Human disorders of hormone production and/or action, such as type 1 and 2 diabetes, obesity, and thyroid disease, affect millions of people globally. In recent decades, an increasing number of hormones have been identified, highlighting the complexity and distributed nature of the endocrine system. RATIONALE: To date, most studies of hormone synthesis and action have focused on a particular hormone, receptor, or target organ. …