果蝇主动寻找黑暗以重置生物钟

Flies seek out darkness to restart their biological clocks Joel D. Levine T he field of chronobiology has largely framed daily bio- logical rhythms as the product of endogenous oscillators synchronized to the 24-hour day by environmental cycles (1–3). In this view, organisms are recipients of temporal in- formation from the environment: Light–dark cycles, tem- perature fluctuations, and social schedules act on cellular “clocks” that in turn organize physiology and behavior. Yet from the earliest human isolation studies, another possibility has remained: Organ- isms do not merely respond to temporal environments; they actively participate in constructing them. On page 98 of this issue, Coculla et al. …