肝脏再生的力学机制

A mechanosensitive ion channel regulates liver cell proliferation after injury Raquel Maeso-Diaz and Anna Mae Diehl For centuries, the liver has been recognized for its remarkable capacity to regenerate after injury. This ability underlies the organ’s resilience to stress and its power to restore home- ostasis after tissue damage and is essential for survival after infection, exposure to toxins, metabolic stress, or ag- ing. Despite decades of research, a central question has remained unresolved: How does the liver sense tissue loss and coordinate regenerative growth while preserving the complex tissue structure required for liver function? On page 59 of this issue, Zhang et al. …