局部信号，系统性衰退

A high-fat diet affects tumor-to-nerve signaling and promotes cachexia in mice Yetiş Gültekin1,2 and Matthew G. Vander Heiden1,2,3,4 Cachexia—a progressive loss of body mass despite adequate nutrition—is one of the most devastating consequences of cancer. However, its causes are incompletely understood. Increased energy expenditure can contribute to cachexia, but “sickness behaviors,” such as loss of appetite (anorexia), fatigue, reduced activity, and malaise, also often play a part (1, 2). Several tumor-derived inflammatory molecules act on the brain and peripheral tissues to promote cachexia in some contexts (1–3), but targeting these factors has not yet led to effective cachexia treatments. On page 90 of this issue, Cross et al. …