The heart puts pressure on cancer growth · W. G. Paltzer and J. F. Martin
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Mechanical forces in the heart prevent tumor expansion in mice Wyatt G. Paltzer1 and James F. Martin1,2,3,4 H eart cancer is very rare in mammals (1). Moreover, the healthy adult heart does not regenerate. Human heart cells (cardiomyocytes) renew at an ~1% rate per year (2). The high mechanical load placed on cardiac tissue, which must overcome strong resistance to pump blood to all body organs, has been proposed to inhibit cardiomyocyte proliferation (3, 4). Indeed, reducing the mechanical load on the heart promotes the expression of cell cycle markers in cardiomyocytes of patients whose hearts were unloaded by a ventricular assist device (5). On page 387 in this issue, Ciucci et al. …
摘自《科学》(Science)第392卷 第6796期 · 2026年4月23日,W. G. Paltzer and J. F. Martin。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。