晨间信号Morning Signal
《科学》 第391卷 第6788期 · 2026年2月26日 · 中文解读

肠道微生物互作失衡作为健康与疾病的标志

Imbalance in gut microbial interactions as a marker of health and disease · R. Corral López et al.
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这篇讲什么
本文介绍了一项研究,该研究开发了一种名为生态网络平衡指数(ENBI)的指标,用于量化肠道微生物群落中正负相互作用的平衡,并发现该指标能稳健地区分健康与疾病状态,且与疾病进展相关。
原文开头
Roberto Corral López, Juan A. Bonachela*†, Maria Gloria Dominguez-Bello, Michael Manhart, Simon A. Levin, Martin J. Blaser, Miguel A. Muñoz*† INTRODUCTION: The human gut microbiome is a complex ecological system crucial for host health. Dysbiosis—i.e., the imbalance of gut microbial communities—is associated with a wide range of diseases, including obesity, diabetes, inflammatory bowel disease (IBD), Clostridioides difficile infection (CDI), irritable bowel syndrome (IBS), and colorectal cancer (CRC). Therapeutic approaches, such as fecal microbiota transplantation, dietary interventions, and probiotics, aim to restore balance by reshaping community composition. However, their outcomes remain inconsistent and unpredictable, in part owing to our limited understanding of the metabolic and ecological interactions that govern microbiome dynamics. …
摘自《科学》(Science)第391卷 第6788期 · 2026年2月26日,R. Corral López et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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