Imbalance in gut microbial interactions as a marker of health and disease · R. Corral López et al.
原文开头
Roberto Corral López, Juan A. Bonachela*†, Maria Gloria Dominguez-Bello, Michael Manhart, Simon A. Levin, Martin J. Blaser, Miguel A. Muñoz*† INTRODUCTION: The human gut microbiome is a complex ecological system crucial for host health. Dysbiosis—i.e., the imbalance of gut microbial communities—is associated with a wide range of diseases, including obesity, diabetes, inflammatory bowel disease (IBD), Clostridioides difficile infection (CDI), irritable bowel syndrome (IBS), and colorectal cancer (CRC). Therapeutic approaches, such as fecal microbiota transplantation, dietary interventions, and probiotics, aim to restore balance by reshaping community composition. However, their outcomes remain inconsistent and unpredictable, in part owing to our limited understanding of the metabolic and ecological interactions that govern microbiome dynamics. …
摘自《科学》(Science)第391卷 第6788期 · 2026年2月26日,R. Corral López et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。