哺乳动物衰老中的全生物体细胞动态与表观基因组重塑

Full article and list of author affiliations: https://doi.org/10.1126/ science.adw6273 Ziyu Lu, Zehao Zhang, Zihan Xu, Abdulraouf Abdulraouf, Wei Zhou*, Junyue Cao* INTRODUCTION: Aging is the leading risk factor for many diseases. This association underscores the potential of therapies targeting the aging process itself to delay or prevent age-related diseases. Substantial advances in single-cell genomics have enabled the profiling of alterations in aging. However, these analyses typically focus on transcriptomics and overlook the impact of chromatin landscapes. RATIONALE: Single-cell assay for transposase-accessible chromatin using sequencing (ATAC-seq), which analyzes genome-wide chromatin accessibility at the single-cell level, has enabled the mapping of the cell type–specific chromatin landscape in a range of mammalian tissues. …