染色质动态塑造跨器官衰老

Age-related chromatin remodeling includes shared and specific signatures across cell types, sex, and organs Sam N. Barnett1,2 and Michela Noseda1,2 Aging governs human lifespan and health span through cellular and molecular mechanisms that are incompletely understood. Over time, aging leads to decline in physiological function and increased vulnerability to disease. A crucial question is whether aging mechanisms can be therapeutically modulated before functional decline begins. A key challenge, however, is understanding these mechanisms to the resolution of individual cells across different organs. Mechanistic differences and similarities between sexes are also poorly understood, despite well-known sex-specific disease risks, such as higher prevalence of autoimmune disease in women or Parkinson’s disease in men (1). …