点亮适配体数据科学的火花

The application of data science to aptamer discovery reveals latent features of enriched libraries Günter Mayer A ptamers are short synthetic nucleic acids that form complex three-dimensional structures, enabling them to bind to target molecules. The binding properties of aptamers have attracted considerable interest in using them for molecular perturbations, detection of disease-related targets, and as tools in synthetic biology. Aptamers are identified through a process known as systematic evolution of ligands by exponential enrichment (SELEX) (1, 2). SELEX is an iterative selection method that uses large libraries of nucleic acids. During this process, the aptamer sequences within these libraries that bind to target molecules are enriched. …